Follistatin 344 (FS344) is a research protein/peptide of significant interest for its interaction with myostatin and activin signalling pathways, which play important roles in the regulation of skeletal muscle development, growth and regeneration.

Follistatin has attracted particular research interest because of its ability to bind and inhibit myostatin, a signalling protein that normally acts as a regulator of skeletal muscle growth.

What is Follistatin 344?

Follistatin is a naturally occurring glycoprotein found throughout the body. It binds members of the transforming growth factor-beta (TGF-β) superfamily, including activin and myostatin.

Follistatin 344 refers to a specific follistatin precursor isoform. Following normal biological processing, FS344 can give rise to the circulating FS315 isoform.

Because of its interaction with the myostatin pathway, FS344 has become an important experimental target in research involving skeletal muscle biology and muscle-wasting disorders.