MOTS-C 20mg

MOTS-c targets skeletal muscle and can enhance glucose metabolism. Therefore, MOTS-c plays an important role in the regulation of cardiovascular, diabetes, exercise and longevity. It is a new mitochondrial signaling mechanism and plays a role in regulating intracellular and intercellular metabolism is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use.

Two other mitochondrial-derived peptides (MDPs) have also been discovered so far, humanin and SHLP1-6, but their possible involvement in human performance enhancement is unknown. According to new research, mitochondrial-derived peptides such as MOTS-c have a role in maintaining mitochondrial function and protecting cells under different stresses1.  It has been shown that exercise causes MOTS-c levels to go up in humans. Furthermore, it has been shown in mice that MOTS-c treatment improves physical performance in mice of all ages and seems to regulate skeletal muscle metabolism and gene expression1.

Are there medical uses for MOTS-c? No, MOTS-c is still an experimental peptide being explored for therapeutic purposes related to aging and obesity. It is not approved by the Food and Drug Administration (FDA) for use in humans. The FDA has also clarified that it is one among many peptides or drugs that are unlawful to use in making compounded medications2. This means that compounding pharmacies (special pharmacies that can custom mix medications) are not supposed to make medications with MOTS-c. Is MOTs-c prohibited in sport? Yes, MOTS-c is prohibited at all times under Section 4.4 Metabolic Modulators, 4.4.1. Activators of the AMP-activated protein kinase (AMPK) on the World Anti-Doping Agency Prohibited List.

Can athletes get a Therapeutic Use Exemption (TUE) for MOTS-c? No, athletes cannot get a TUE for MOTS-c because there is no approved therapeutic use for this experimental drug. Is MOTS-c used in dietary supplements? No, MOTS-c is not a legitimate dietary ingredient and cannot legally be used in dietary supplements.   Is MOTS-c safe to use? Currently it is unknown under what conditions (if any) it is safe to use MOTS-c because there are no completed clinical trials. However, among people who claim to purchase MOTS-c online, there are many reported side effects, including increased heart rate or heart palpitations, injection site irritation, insomnia, and fever. There is also no data available on what happens with long-term use of MOTS-c.