ARA-290 — Research Peptide

ARA-290, also known as Cibinetide, is an 11-amino-acid synthetic peptide derived from the tissue-protective region of erythropoietin (EPO). Unlike EPO, ARA-290 was designed to activate tissue-protective pathways without stimulating red blood cell production.

ARA-290 has attracted research interest particularly in the fields of nerve health, inflammatory signalling, tissue protection and small-fiber neuropathy.

Key Research Areas

Nerve & Neuropathy Research
ARA-290 has been investigated extensively in experimental and human clinical research involving small-fiber neuropathy and neuropathic symptoms. Studies have reported changes in neuropathic symptoms and measures of small nerve-fiber density.

Tissue Protection & Repair
ARA-290 is designed to interact with the innate repair receptor (IRR), a signalling system associated with cellular protection and tissue-repair responses following injury or inflammation.

Inflammatory Pathways
Research suggests activation of the innate repair receptor may influence inflammatory signalling while promoting protective and restorative cellular responses. This has made ARA-290 particularly interesting for research into inflammation-associated tissue and nerve damage.

Small-Fiber Nerve Regeneration
Clinical studies involving people with sarcoidosis-associated small-fiber neuropathy reported improvements in neuropathic symptoms alongside increases in corneal nerve-fiber density, an objective marker used to assess small nerve fibers.

Metabolic & Diabetic Neuropathy Research
ARA-290 has also been studied in subjects with type 2 diabetes and painful neuropathy. A Phase 2 study reported improvements in certain neuropathic symptoms and metabolic measurements, although these findings require further clinical investigation.

How ARA-290 Works

ARA-290 was engineered from the three-dimensional structure of erythropoietin. Its proposed mechanism involves activation of the innate repair receptor, rather than the classical EPO pathway responsible for red-blood-cell production.

Researchers are investigating this pathway for its potential role in:

• Cellular and tissue protection
• Regulation of inflammatory responses
• Peripheral nerve repair
• Small nerve-fiber regeneration
• Recovery following tissue injury

Human clinical trials have evaluated ARA-290/Cibinetide at several experimental doses, but these studies should not be interpreted as establishing a standard human treatment or dosing protocol.

Product Information

Product: ARA-290 (Cibinetide)
Form: Lyophilized Powder
Category: Research Peptide
Research Focus: Neuropathy, nerve regeneration, inflammation and tissue-protection pathways

Research Use Only: Not for human or veterinary use.